Inhibition of histone deacetylase activity interferes with innate immune responses and protects from severe sepsis

ABSTRACT: Sensing of microbial products by innate immune cells skew their transcriptional program to optimize anti-microbial defences. Chromatin remodeling by histone deacetylases (HDACs) plays a fundamental role in tailoring gene expression. HDAC inhibitors are among the most promising anti-cancer drugs and possess intrinsic anti-inflammatory properties. Yet, the influence of HDAC inhibition on innate immune responses to microbial infection is unknown. Here we show that HDAC inhibitors repress the expression of less than 10% of the genes expressed at baseline in BM-derived macrophages. In sharp contrast, HDAC inhibitors strongly interfere with transcriptome remodeling induced by LPS and Pam3CSK4, affecting the expression of 30-70% of genes modulated by microbial stimuli. Strikingly, HDAC inhibitors

ORGANISM(S): Mus musculus

SUBMITTER: FRANCOIS Patrice 

PROVIDER: E-GEOD-22409 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress