Comparison of gene expression between wild type, Notch1-activated, and RBPJ loss-of-function embryonic mouse yolk sac tissue at E9.5

ABSTRACT: The signaling cascades that direct the morphological differentiation of the vascular system during early embryogenesis are not well defined. To further understand the role of Notch signaling during endothelial differentiation, this study uses both an in vivo gain-of-function and in vivo loss-of-function approach. At embryonic day 9.5, embryos with activated Notch1 signaling in the endothelia display a variety of growth and cardiovascular defects, and die soon after E10.5. Most notably, the extra-embryonic vasculature of the yolk sac displays remodeling differentiation defects. In the wild-type yolk sac, the primary vascular network has begun to reorganize, forming the large primary vessels and the smaller capillaries. In the activated Notch1 embryos remodeling is defective; the vascul

ORGANISM(S): Mus musculus

SUBMITTER: Jay Vivian 

PROVIDER: E-GEOD-22418 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress