Group A Streptococcus Gene Expression in Humans with Pharyngitis Using a Microarray

ABSTRACT: This study represents the first in vivo genome wide analysis of gene epxression of Group A Streptococcus (GAS) in humans with pharyngitis. The micorarray used is a custom microarray that relies on an electrochemical reaction as the measured signal rather than flourescence. Distinct clusters of gene expression were discovered and analyzed. A functional analysis examining differences and similarities between the clusters was performed. Samples were taken from pediatric patients who had received a throat swab as part of their clinical care for evaluating pharyngitis. Eleven samples that were culture postive for GAS were used along with 3 samples from subjects who were GAS culture negative. The microarray was a composite comprised of 12,000 probes, representing 2724 GAS open reading frames b

ORGANISM(S): Homo sapiens

SUBMITTER: Luis Perez 

PROVIDER: E-GEOD-22436 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress