The COP9 signalosome mediates transcriptional and metabolic response during fungal development

ABSTRACT: The COP9 signalosome complex (CSN) is a crucial regulator of ubiquitin ligases. Defects in CSN result in embryonic impairment and death in higher eukaryotes, whereas the filamentous fungus Aspergillus nidulans survives without CSN, but is unable to complete sexual development. We investigated overall impact of CSN activity on A. nidulans cells by combined transcriptome, proteome and metabolome analysis. Absence of csn5/csnE affects transcription of at least 15 % of genes during development, including numerous oxidoreductases. csnE deletion leads to changes in the fungal proteome indicating impaired redox regulation and hypersensitivity to oxidative stress. CSN promotes the formation of asexual spores by regulating developmental hormones produced by PpoA and PpoC dioxygenases. We identify m

ORGANISM(S): Emericella nidulans

SUBMITTER: Lennart Opitz 

PROVIDER: E-GEOD-22442 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress