Custom MHC array analysis of lymphoblastoid cell lines

ABSTRACT: The human MHC is a paradigm for genomics, showing striking association with disease but functional variants remain largely unresolved. Using an original hybrid microarray (containing tiling and junction probes) for the MHC and accounting for known sequence diversity, we have drawn the first high-resolution, strand-specific transcriptional map of the MHC, defining differences in gene expression for three common haplotypes associated with autoimmune disease. In total, 6% of the MHC is transcribed with one transcript per 1.4kb, including previously unrecognized intergenic transcription. The distributions of differentially expressed probes and polymorphisms between haplotypes are significantly correlated, arguing for cis effects. Haplotype-specific transcription involved 96 differentially expr

ORGANISM(S): Homo sapiens

SUBMITTER: Claire Vandiedonck 

PROVIDER: E-GEOD-22453 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress