CGH profiles of primary breast carcinomas from HBOC (Hereditary Breast and Ovarian Cancer) families
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Simon Joosse
PROVIDER: E-GEOD-22481 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Prediction of BRCA2-association in hereditary breast carcinomas using array-CGH.
Joosse Simon A SA Brandwijk Kim I M KI Devilee Peter P Wesseling Jelle J Hogervorst Frans B L FB Verhoef Senno S Nederlof Petra M PM
Breast cancer research and treatment 20100708 2
Germline mutations in BRCA1/2 increase the lifetime risk for breast and ovarian cancer dramatically. Identification of such mutations is important for optimal treatment decisions and pre-symptomatic mutation screening in family members. Although current DNA diagnostics is able to identify many different mutations, it remains unclear, how many BRCA2-associated breast cancer cases remain unidentified as such. In addition, mutation scanning detects many unclassified variants (UV) for which the clin ...[more]
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