CGH profiles of primary breast carcinomas from HBOC (Hereditary Breast and Ovarian Cancer) families

ABSTRACT: 89 tumors from women that were eligible for, and subjected to, routine diagnostic testing according to the HBOC criteria but were negative for pathogenic BRCA1/2-mutations or carried an UV in either BRCA1/2 A BRCA2-classifier was built using array-CGH profiles of 28 BRCA2-mutated and 28 sporadic breast tumors. The classifier was validated on an independent group of 19 BRCA2-mutated and 19 sporadic breast tumors. Subsequently, we tested 89 breast tumors from suspected hereditary breast (and ovarian) cancer (HBOC) families, in which either no BRCA1/2 mutation or an UV had been found by routine diagnostics.

ORGANISM(S): Homo sapiens

SUBMITTER: Simon Joosse 

PROVIDER: E-GEOD-22481 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress