Trancription profiling of breast tumor biopsies to identify markers of Taxane Sensitivity in Breast Cancer

ABSTRACT: The purpose of this study was to identify molecular markers of pathologic response to neoadjuvant paclitaxel/radiation treatment, protein and gene expression profiling were done on pretreatment biopsies. Patients with high-risk, operable breast cancer were treated with three cycles of paclitaxel followed by concurrent paclitaxel/radiation. Tumor tissue from pretreatment biopsies was obtained from 19 of the 38 patients enrolled in the study. Protein and gene expression profiling were done on serial sections of the biopsies from patients that achieved a pathologic complete response (pCR) and compared to those with residual disease, non-pCR (NR). Proteomic and validation immunohistochemical analyses revealed that α-defensins (DEFA) were overexpressed in tumors from patients with a pCR. Gen

ORGANISM(S): Homo sapiens

SUBMITTER: Jennifer Pietenpol 

PROVIDER: E-GEOD-22513 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress