Gene expression in primate postnatal brain through lifespan - prefrontal cortex

ABSTRACT: We investigated molecular changes during human, chimpanzee, and rhesus macaque postnatal brain development at the transcriptome, proteome, and metabolome levels in two brain regions: the prefrontal cortex (PFC) that is involved in several human-specific cognitive processes, and the cerebellar cortex (CBC) that may be functionally more conserved. We find a nearly three-fold excess of human-specific gene expression changes in PFC compared to CBC. The most prominent human-specific mRNA expression pattern in the PFC is a developmental delay of approximately 5 years in the expression of genes associated with learning and memory, such as synaptic transmission and long-term potentiation. This pattern is supported by correlated changes in concentrations of proteins and the respective neurotransmit

ORGANISM(S): Macaca mulatta

SUBMITTER: Mehmet Somel 

PROVIDER: E-GEOD-22521 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress