Anti-CD3 therapy permits regulatory T cells to surmount T cell receptor-specified peripheral niche constraints

ABSTRACT: Treatment with anti-CD3 is a promising therapeutic approach for autoimmune diabetes, but its mechanism of action remains unclear. Foxp3+ regulatory T (Treg) cells may be involved, but the evidence has been conflicting, and there is great uncertainty as to possible mechanistic connections. We investigated this issue in mice derived from the NOD model, which were engineered mice in which Treg populations were perturbed, or could be manipulated by acute ablation or transfer. The data highlighted the involvement of Foxp3+ cells in anti-CD3 action. Rather than a generic influence on all Treg cells, the therapeutic effect seemed to involve an striking expansion of previously constrained Treg cell populations; this expansion occurred not through conversion from Foxp3- Tconv cells but from a drama

ORGANISM(S): Mus musculus

SUBMITTER: Christophe Benoist 

PROVIDER: E-GEOD-22527 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress