Meningioma initiating cells (MICs) derived from primary tumors

ABSTRACT: The majority of meningiomas are benign tumors associated with favorable outcomes; however, the less common aggressive variants with unfavorable outcomes often recur and may be due to sub-populations of less-differentiated cells residing within the tumor. These sub-populations of tumor cells, termed tumor-initiating cells, may be isolated from heterogeneous tumors when sorted or cultured in defined medium designed for enrichment of the tumor-initiating cells. We report the isolation and characterization of a population of tumor-initiating cells derived from an atypical meningioma. These meningioma-initiating cells (MICs) self-renew, differentiate, and can recapitulate the histological characteristics of the parental tumor when transplanted into athymic nude mice. Immunohistochemistry re

ORGANISM(S): Homo sapiens

SUBMITTER: Huidong Shi 

PROVIDER: E-GEOD-22577 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress