A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells

ABSTRACT: Dendritic cells (DC) serve a key function in host defense, linking innate detection of microbes to the activation of pathogen-specific adaptive immune responses. Whether there is cell-intrinsic recognition of HIV-1 by host innate pattern-recognition receptors and subsequent coupling to antiviral T cell responses is not yet known. DC are largely resistant to infection with HIV-1, but facilitate infection of co-cultured T-helper cells through a process of trans-enhancement. We show here that, when DC resistance to infection is circumvented, HIV-1 induces DC maturation, an antiviral type I interferon response and activation of T cells. This innate response is dependent on the interaction of newly-synthesized HIV-1 capsid (CA) with cellular cyclophilin A (CypA) and the subsequent activation of

ORGANISM(S): Homo sapiens

SUBMITTER: Dan Littman 

PROVIDER: E-GEOD-22589 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress