Intrathymic T-cell selection
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Xiaolong Liu
PROVIDER: E-GEOD-2262 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
The zinc finger protein cKrox directs CD4 lineage differentiation during intrathymic T cell positive selection.
Sun Guangping G Liu Xiaolong X Mercado Peter P Jenkinson S Rhiannon SR Kypriotou Magdalini M Feigenbaum Lionel L Galéra Philippe P Bosselut Rémy R
Nature immunology 20050306 4
The genetic programs directing CD4 or CD8 T cell differentiation in the thymus remain poorly understood. While analyzing gene expression during intrathymic T cell selection, we found that Zfp67, encoding the zinc finger transcription factor cKrox, was upregulated during the differentiation of CD4(+) but not CD8(+) T cells. Expression of a cKrox transgene impaired CD8 T cell development and caused major histocompatibility complex class I-restricted thymocytes to differentiate into CD4(+) T cells ...[more]
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