Identification of neural genes using Xenopus DNA microarrays

ABSTRACT: In order to isolate novel genes regulating neural induction, we utilized a DNA microarray approach. As neural induction is thought to occur via the inhibition of BMP signaling, BMP signaling was inhibited in ectodermal cells by overexpression of a dominant-negative receptor. RNAs were isolated from control animal cap explants and from dominant-negative BMP receptor expressing animal caps and subjected to a microarray experiment using newly generated high-density Xenopus DNA microarray chips. Keywords = neural induction Keywords = BMP Keywords = nervous system Keywords = Xenopus Keywords = microarray

ORGANISM(S): Xenopus laevis

SUBMITTER: Makoto Mochii 

PROVIDER: E-GEOD-2266 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress