Transcriptome of Mycoplasma genitalium under osmotic stress

ABSTRACT: Mycoplasma genitalium is the causative agent of non-gonococcal, chlamydia-negative urethritis in men and has been linked to reproductive tract disease syndromes in women. As with other mycoplasmas, M. genitalium lacks many regulatory genes because of its streamlined genome and total dependence on a parasitic existence. Therefore, it is important to understand how gene regulation occurs in M. genitalium, particularly in response to environmental signals likely to be encountered in vivo. In this study, we developed an oligonucleotide-based microarray to investigate transcriptional changes in M. genitalium following osmotic shock. Using a physiologically relevant osmolarity condition (0.3 M sodium chloride), we identified 39 up-regulated and 72 down-regulated genes. Of the up-regulated genes

ORGANISM(S): Mycoplasma genitalium

SUBMITTER: Wenbo Zhang 

PROVIDER: E-GEOD-22661 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress