Gene expression changes in the female zebrafish (Danio rerio) brain in response to acute exposure to methylmercury

ABSTRACT: Methylmercury (MeHg) is a potent neurotoxin and endocrine disruptor that accumulates in aquatic systems. Previous studies have shown suppression of hormone levels in both male and female fish, suggesting effects on gonadotropin regulation in the brain. We investigated the gene expression profile in adult female zebrafish whole brain induced by acute (96 hr) MeHg exposure. Fish were exposed by injection to 0 or 0.5 M-BM-5g MeHg/g. Gene expression changes in the brain were examined using a two-color 22,000 feature zebrafish microarray. At a significance level of p<0.01, 79 genes were up-regulated and 76 genes were down-regulated in response to MeHg exposure. Individual genes exhibiting altered expression in response to MeHg exposure implicate effects on glutathione metabolism and GABA-A rece

ORGANISM(S): Danio rerio

SUBMITTER: Natalia Vinas 

PROVIDER: E-GEOD-22662 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress