Regulation of gene expression program by Fsp27 in white and brown adipose tissue

ABSTRACT: Background: Brown and white adipose tissues (BAT and WAT) play critical roles in controlling energy homeostasis and in the development of obesity and diabetes. Fsp27 is expressed in both BAT and WAT and promotes lipid storage and the development of obesity and diabetes. In addition, Fsp27-deficient white adipocytes acquired certain BAT-like properties including reduced lipid droplet size and increased mitochondrial activity. Using microarray and semi-quantitative real-time PCR analyses, we systematically analyzed the gene expression profile in Fsp27-deficient WAT and BAT. Results: We observed that BAT-selective genes were significantly up-regulated, whereas WAT-selective genes were down-regulated in the WAT of Fsp27-/- mice. Expression levels of BAT-selective genes were also dramatically u

ORGANISM(S): Mus musculus

SUBMITTER: Yinxin Zhang 

PROVIDER: E-GEOD-22693 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress