Absence of significant overlap in transcriptional patterns between operationally tolerant liver and kidney recipients

ABSTRACT: Transplant recipients spontaneously accepting their grafts in the absence of immunosuppression demonstrate the feasibility of attaining allograft tolerance in humans. Previous studies have identified blood transcriptional and cell phenotypic markers specific for either liver or kidney tolerant recipients, but the two settings have not been directly compared yet employing the same platforms. To identify potential similarities in immune parameters between recipients tolerant to different organs, we analyzed blood samples from tolerant and non-tolerant liver and kidney recipients employing whole genome expression microarrays. Tolerant and non-tolerant liver and kidney recipients differed in their peripheral blood expression patterns, but no significant overlap was observed between the two dat

ORGANISM(S): Homo sapiens

SUBMITTER: Juanjo Lozano 

PROVIDER: E-GEOD-22707 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress