Transcription profiling of mouse lung to study the effect of prostaglandin E receptor subtype EP3 on mouse asthma model.
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Eri Segi-Nishida
PROVIDER: E-GEOD-2276 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Suppression of allergic inflammation by the prostaglandin E receptor subtype EP3.
Kunikata Tomonori T Yamane Hana H Segi Eri E Matsuoka Toshiyuki T Sugimoto Yukihiko Y Tanaka Satoshi S Tanaka Hiroyuki H Nagai Hiroichi H Ichikawa Atsushi A Narumiya Shuh S
Nature immunology 20050403 5
Prostaglandins, including PGD(2) and PGE(2), are produced during allergic reactions. Although PGD(2) is an important mediator of allergic responses, aspirin-like drugs that inhibit prostaglandin synthesis are generally ineffective in allergic disorders, suggesting that another prostaglandin-mediated pathway prevents the development of allergic reactions. Here we show that such a pathway may be mediated by PGE(2) acting at the prostaglandin E receptor EP3. Mice lacking EP3 developed allergic infl ...[more]
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