Autocrine IL-1α mediates NF-κB activation by oncogenic ras in keratinocytes

ABSTRACT: Constitutively active RAS plays a central role in the development of skin cancer in the classical two stage skin carcinogenesis in mice and in a number of human cancers. Ras-mediated tumor formation is commonly associated with upregulation of cytokines and chemokines that mediate an inflammatory response considered relevant to oncogenesis. MyD88 is a crucial intermediate in the expression of multiple innate immune responders through signaling from the Toll-like/IL-1R family. We report that mice ablated for MyD88 or the IL-1R are resistant to topical skin carcinogenesis, and cultured MyD88-/- keratinocytes transduced with an oncogenic ras vector form only a few small tumors in orthotopic grafts. Initiated keratinocytes arising from oncogenic activation of ras are hyperproliferative but also

ORGANISM(S): Mus musculus

SUBMITTER: Rosalba Salcedo 

PROVIDER: E-GEOD-22777 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress