Gene transcription profiles and potential transgenerational epigenetic effects related to Zn exposure history in Daphnia magna

ABSTRACT: A reduced level of DNA methylation has recently been described in both Zn-exposed and non-exposed offspring of Daphnia magna exposed to Zn. The hypothesis examined in this study is that DNA hypomethylation has an effect on gene transcription. A second hypothesis is that accumulative epigenetic effects can affect gene transcription in non-exposed offspring from parents with an exposure history of more than one generation. Transcriptional gene regulation was studied with a cDNA microarray. In the exposed and non-exposed hypomethylated daphnids, a large proportion of common genes were similarly up- or downregulated, indicating a possible effect of the DNA hypomethylation. Two of these genes can be mechanistically involved in DNA methylation reduction. The similar transcriptional regulation of

ORGANISM(S): Daphnia magna

SUBMITTER: Michiel Vandegehuchte 

PROVIDER: E-GEOD-22805 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress