Transcriptomic dysregulation in aggressive and malignant prolactin tumours

ABSTRACT: Pituitary tumours are generally benign. However, many are invasive and some of these are aggressive with high proliferation and recurrence rates. Only metastatic tumours are considered malignant and are rare (0.2%). To identify molecular events associated with the aggressive and malignant phenotypes, we combined a comparative genomic hybridization and transcriptomic analysis of 13 prolactin (PRL) tumours classified as non-invasive (NI; n=5), invasive (I; n=2) or aggressive-invasive (AI; n=6). Each tumour showed copy number alterations which appeared to be varied and discrete in the NI and I tumour groups, and more numerous and extensive in the AI tumour group. Allelic loss within the p arm region of chromosome 11 was detected in five of the AI tumours. This region contains the cytobands 11

ORGANISM(S): Homo sapiens

SUBMITTER: JoM-CM-+l LACHUER 

PROVIDER: E-GEOD-22812 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress