Transcriptional response of Sacchromyces cerevisiae to change in oxygen provision

ABSTRACT: In industrial fermentations of Saccharomyces cerevisiae, transient changes in oxygen concentration commonly occur and it is important to understand the behaviour of cells during these changes. Saccharomyces cerevisiae CEN.PK113-1A was grown in glucose-limited chemostat culture with 1.0% and 20.9% O2 in the inlet gas (D= 0.10 /h, pH5, 30C). After steady state was achieved, oxygen was replaced with nitrogen and cultures were followed until new steady state was achieved. The overall responses to anaerobic conditions of cells initially in different conditions were very similar. Independent of initial culture conditions, transient downregulation of genes related to growth and cell proliferation, mitochondrial translation and protein import, and sulphate assimilation was seen. In addition, trans

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Eija Rintala 

PROVIDER: E-GEOD-22832 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress