Retinal pigment epithelial cells suppress interleukin-17-producing T-helper 17 cells

ABSTRACT: T cells that encounter cultured ocular pigment epithelial cells in vitro are inhibited from undergoing T cell receptor-triggered activation. Because retinal pigment epithelial (RPE) cells are able to suppress T-cell activation, we studied whether RPE cells could suppress cytokine production by activated T helper (Th) cells. In this study we showed that primary cultured RPE cells greatly suppressed activation of bystander CD4+ T cells in vitro, especially the cytokine production by the target T helper cells (Th1 cells, Th2 cells, Th17 cells, but not Th3 cells). Cultured RPE cells and RPE-supernatants significantly suppressed IL-17 producing CD4+ T cells, and RPE cells fully suppressed polarized Th17 cell lines that induced by recombinant proteins, IL-6 and TGFb2. Moreover, RPE cells fai

ORGANISM(S): Mus musculus

SUBMITTER: Sunao Sugita 

PROVIDER: E-GEOD-22877 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress