MicroRNA profiling in Mouse Eye: Retina, Lens, Cornea, Retinal Pigment Epithelium

ABSTRACT: MicroRNA expression in the mouse eye.MicroRNAs (miRNAs) are key regulators of biological processes. To define miRNA function in the eye, it is essential to determine a high-resolution profile of their spatial and temporal distribution. In this report, we present the first comprehensive survey of miRNA expression in ocular tissues, using both microarray and RNA in situ hybridization (ISH) procedures. We initially determined the expression profiles of miRNAs in the retina, lens, cornea and retinal pigment epithelium of the adult mouse eye by microarray. Each tissue exhibited notably distinct miRNA enrichment patterns and cluster analysis identified groups of miRNAs that showed predominant expression in specific ocular tissues or combinations of them. Next, we performed RNA ISH for over 220

ORGANISM(S): Mus musculus

SUBMITTER: Marianthi Karali 

PROVIDER: E-GEOD-22882 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress