The Molecular Signature Induced by HMGA1 During Lymphoid Tumorigenesis

ABSTRACT: We are exploring the molecular pathways activated during lymphoid transformation with the long term goal of developing better therapies. Our focus is the HMGA1a oncogene because our studies indicate that it plays an important role in aggressive human lymphoid leukemia and lymphoma. We have developed the transgenic mouse over-expressing HMGA1a in lymphoid cells that develop aggressive lymphoid tumors by 8-10 months with histopathologic findings resembling human T-cell acute lymphocytic leukemia. By analyzing the gene expression profiles of our HMGA1a mouse model we plan to identify molecular pathways activated by HMGA1a in lymphoid transformation. Results from these studies will enhance our understanding of the pathogenesis of lymphoid malignancies and should lead to the development of bett

ORGANISM(S): Mus musculus

SUBMITTER: Linda Resar 

PROVIDER: E-GEOD-22922 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress