Effects of diet and age on canine liver gene expression

ABSTRACT: The liver is the central organ in the regulation of nutrient metabolism, xenobiotic metabolism, and detoxification. Aging leads to a marked change in liver structure and function, characterized by a decline in weight, blood flow, regeneration rate, and detoxification. However, the mechanisms that contribute to these changes are poorly described. Global gene expression profiles of aged versus young adult dogs have not been compared previously. Thus, we used canine microarrays to compare gene expression profiles of liver tissue from geriatric and young adult dogs fed 2 different diets. Liver tissue samples were collected from 6 geriatric (12 yr-old) and 6 young adult (1 yr-old) female beagles after being fed one of two diets (animal protein-based versus plant-protein based) for 12 month

ORGANISM(S): Canis lupus familiaris

SUBMITTER: Kelly Swanson 

PROVIDER: E-GEOD-22945 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress