Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcriptome analysis of mouse cerebral cortical neural progenitor cells


ABSTRACT: Transcriptome analysis of neural progenitor/stem cells is limited by the lack of a reliable method for cell isolation. We have designed a genetic dual reporter strategy that can allow prospective isolation of cortical neural progenitor cells and their neuronal progeny form the same animals. These cells should be a good cell source for comparative global analysis. Cortical neural progenitor cells and their neuronal progeny were purified using a dual reporter strategy. The purified cells were used for comparative expression profiling.

ORGANISM(S): Mus musculus

SUBMITTER: Xiwei Wu 

PROVIDER: E-GEOD-22946 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Transcriptome analysis of neural progenitor cells by a genetic dual reporter strategy.

Wang Jun J   Zhang Heying H   Young Amanda G AG   Qiu Runxiang R   Argalian Siranush S   Li Xuejun X   Wu Xiwei X   Lemke Greg G   Lu Qiang Q  

Stem cells (Dayton, Ohio) 20111001 10


Global analysis of stem/progenitor cells promises new insight into mechanisms that govern self-renewal and cellular potential, an unresolved question of stem/progenitor cell biology. Despite rapid advance of genome-wide profiling methods, the difficulty in cell purification remains a major challenge for global analysis of somatic stem/progenitor cells. Genetic tagging with a reporter provides a powerful tool for identification and isolation of a specific mature cell type; however, for stem/proge  ...[more]

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