Global analysis of RAR-responsive genes in the Xenopus neurula

ABSTRACT: Retinoid signaling is important for patterning the vertebrate hindbrain and midaxial regions. We recently showed that signaling through retinoic acid receptors (RARs) is essential for anteroposterior patterning along the entire body axis. To further investigate the mechanisms through which RARs act, we employed microarray analysis to investigate the effects of modulating RAR activity on target gene expression. We identified 334 upregulated genes (92% of which were validated) including known RA responsive genes, known genes that have never been proposed as RA targets and many hypothetical and unidentified genes (n = 166). 67 validated downregulated genes were identified including known RA responsive genes and anterior marker genes. The expression patterns of selected upregulated genes (n =

ORGANISM(S): Xenopus laevis

SUBMITTER: Jason Shiotsugu 

PROVIDER: E-GEOD-2295 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress