Dataset Information
Transcription profiling of human HLE B-3 cells transfected with hGSTA4-4 expressing vector vs. controls
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Brad Allen Patrick
PROVIDER: E-GEOD-2298 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Depletion of 4-hydroxynonenal in hGSTA4-transfected HLE B-3 cells results in profound changes in gene expression.
Biochemical and biophysical research communications 20050801 2
Previously, we have shown that overexpression of 4-hydroxy-2-nonenal (HNE)-detoxifying enzyme glutathione S-transferase A4-4 (hGSTA4-4) in human lens epithelial cells (HLE B-3) leads to pro-carcinogenic phenotypic transformation of these cells [R. Sharma, et al. Eur. J. Biochem. 271 (2004) 1960-1701]. We now demonstrate that hGSTA4-transfection also causes a profound change in the expression of genes involved in cell adhesion, cell cycle control, proliferation, cell growth, and apoptosis, which ...[more]
