Combinatorial effects of microRNA to suppress the myc oncogenic pathway

ABSTRACT: Many mammalian transcripts contain target sites for multiple miRNAs, although it is not clear to what extent miRNAs may coordinately regulate single genes. We have mapped the interactions between down-regulated miRNAs and overexpressed target protein-coding genes in murine and human lymphomas. Myc, one of the hallmark oncogenes in these lymphomas, stands out as the up-regulated gene with the highest number of genetic interactions with down-regulated miRNAs in mouse lymphomas. The regulation of Myc by several of these miRNAs is confirmed by cellular and reporter assays. The same approach identifies MYC and multiple Myc targets as a preferential target of down-regulated miRNAs in human Burkitt lymphoma, a pathology characterized by translocated MYC oncogenes. These results indicate that seve

ORGANISM(S): Homo sapiens

SUBMITTER: Lorena Di Lisio 

PROVIDER: E-GEOD-23026 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress