Transcription profiling of rat liver samples treated with clofibrate, valproic acid and diethylhexylphthalate

ABSTRACT: The project had 2 goals:; 1) To evaluate the transcriptional response of 3 prototypical toxicants (Clofibrate, VPA, and DEHP) on rat lever. 2) To evaluate the impact pooling samples has on data analysis. Experiment Overall Design: Male SD rats were given a single dose of one of 3 prototypical toxicants or dosed with vehicle. The toxicants used were: Experiment Overall Design: 1000mg/kg Clofibrate (in 0.9% saline) Experiment Overall Design: 2000mg/kg Sodium Valproate (in distilled water) Experiment Overall Design: 20g/kg DEHP (in distilled water) Experiment Overall Design: Animals were sacrificed at 4, 24, 48, or 168hrs post-dosing (only 48 and 168hrs for vehicle-treated animals) Experiment Overall Design: One of the goals of this study was to assess the impact pooling RNA samples has on th

ORGANISM(S): Rattus norvegicus

SUBMITTER: Keith Goldstein 

PROVIDER: E-GEOD-2303 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress