Autocatalytic differentiation of epigenetic modifications within the Arabidopsis genome
Ontology highlight
ABSTRACT:
ORGANISM(S): Arabidopsis thaliana
SUBMITTER: Soichi Inagaki
PROVIDER: E-GEOD-23030 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Autocatalytic differentiation of epigenetic modifications within the Arabidopsis genome.
Inagaki Soichi S Miura-Kamio Asuka A Nakamura Yasukazu Y Lu Falong F Cui Xia X Cao Xiaofeng X Kimura Hiroshi H Saze Hidetoshi H Kakutani Tetsuji T
The EMBO journal 20100910 20
In diverse eukaryotes, constitutively silent sequences, such as transposons and repeats, are marked by methylation at histone H3 lysine 9 (H3K9me). Although selective H3K9me is critical for maintaining genome integrity, mechanisms to exclude H3K9me from active genes remain largely unexplored. Here, we show in Arabidopsis that the exclusion depends on a histone demethylase gene, IBM1 (increase in BONSAI methylation). Loss-of-function ibm1 mutation results in ectopic H3K9me and non-CG methylation ...[more]
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