Gene expression signatures and molecular markers predict response to therapy in locally advanced head and neck squamous cell carcinoma.

ABSTRACT: Locally advanced head and neck squamous cell carcinomas (HNSCC) are commonly treated with chemoradiotherapy (CRT) or induction chemotherapy followed by radiotherapy/CRT or surgery. The purpose of our study was to identify expression signatures and molecular markers able to anticipate tumor response to therapy and clinical outcome. We performed a study with 63 pre-treatment tumor biopsies from locally advanced HNSCC treated with either of the two standard treatments. Cluster analysis identified three tumor subtypes associated with significant differences in local recurrence-free survival (LRFS) and overall survival (OS). Tumor subtype 1, associated with low LRFS and OS, showed features of epithelial-mesenchymal transition and undifferentiation. It also overexpressed genes related to cell

ORGANISM(S): Homo sapiens

SUBMITTER: MIGUEL ANGEL PAVON 

PROVIDER: E-GEOD-23036 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress