Diclofenac affects global hepatic gene expression in fish at plasma concentrations similar to human therapeutic levels

ABSTRACT: Background: Diclofenac is a non-steroidal anti-inflammatory drug frequently found in the aquatic environment. Previous studies have reported histological changes in the liver, kidney and gills of fish at concentrations similar to those measured in treated sewage effluents (~1 µg/L). Analyses or predictions of blood plasma levels in fish allow a direct comparison with human therapeutic plasma levels, and may therefore be used to indicate a risk for pharmacological effects in fish. To relate internal exposure to a pharmacological interaction we therefore investigated global hepatic gene expression together with bioconcentration to blood plasma and liver of rainbow trout (Oncorhynchus mykiss) exposed to waterborne diclofenac. Results: At the highest exposure (81.5µg/L) the fish plasma concen

ORGANISM(S): Oncorhynchus mykiss

SUBMITTER: Erik Kristiansson 

PROVIDER: E-GEOD-23053 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress