The expression programme of ERR-alphain human mammary epithelial cells

ABSTRACT: This dataset is part of the manuscript titled "The metabolic regulator ERRalpha, a downstream target of HER2/IGF1, as a therapeutic target in breast cancer" (in review). The expression data obtained in human mammary epithelial cells were used to generate a list of ERRalpha-regulated genes that was later refined in clinical breast cancer datasets to generate a clinically relevant signature of ERalpha activity (referred to as Cluster 3 signature). Using this signature of the estrogen-related receptor alpha (ERRa) to profile more than eight-hundred breast tumors, we found that patients with tumors exhibiting higher ERRa activity were predicted to have shorter disease free survival. Further, the ability of an ERRa antagonist, XCT790, to inhibit breast cancer cell proliferation correlates with

ORGANISM(S): Homo sapiens

SUBMITTER: Dmitri Kazmin 

PROVIDER: E-GEOD-23061 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress