Gene Expression Profiles in a Rabbit Model of Systemic Lupus Erythematosus

ABSTRACT: We previously reported the establishment of a rabbit (Oryctolagus cuniculus) model of Systemic Lupus Erythematosus (SLE) in which peptide immunization led to lupus-like autoantibody production including anti-Sm, -RNP, -SS-A, -SS-B and -dsDNA. Some neurological symptoms in form of seizures and nystagmus were observed. The animals used in the previous and in the present study were from a National Institute of Allergy and Infectious Diseases colony of rabbits that were pedigreed, immunoglobulin allotype-defined but not inbred. Their genetic heterogeneity may correspond to that found among patients of a given ethnicity. We extended the information about this rabbit model of SLE by microarray based expression profiling. We first demonstrated that human expression arrays could be used with rab

ORGANISM(S): Oryctolagus cuniculus

SUBMITTER: Richard Lempicki 

PROVIDER: E-GEOD-23076 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress