Cellular response to protein-conjugated nanoparticles

ABSTRACT: Interaction of nanomaterials with the mammalian cells remains to be poorly understood at the molecular level. Here we report the first synthesis of hybrid nanomaterial termed phage mimetic nanorods (PMN’s) inspired from filamentous bacteriophage present in nature. We emulate filamentous bacteriophage structure by combining two separate nanoscale entities, one functionalized gold nanorods and the other is coat proteins isolated from filamentous bacteriophage obtained through landscape phage screening. Utilizing biochemical interactions between a phage-derived protein and functionalized gold nanorods, we synthesized novel phage mimetic nanorods. The resulting nanovectors showed excellent multi functional properties including target specificity, imaging and photo destruction ability in a mode

ORGANISM(S): Homo sapiens

SUBMITTER: Mikhail Dozmorov 

PROVIDER: E-GEOD-23118 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress