Global transcriptomic profiling of ischemic/reperfusion injury in an in vivo mouse model.
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Minghui Jessica Chen
PROVIDER: E-GEOD-23163 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
A global transcriptomic view of the multifaceted role of glutathione peroxidase-1 in cerebral ischemic-reperfusion injury.
Chen Minghui Jessica MJ Wong Connie H Y CH Peng Zhao Feng ZF Manikandan Jayapal J Melendez Alirio J AJ Tan Theresa M TM Crack Peter J PJ Cheung Nam Sang NS
Free radical biology & medicine 20101228 6
Transient cerebral ischemia often results in secondary ischemic/reperfusion injury, the pathogenesis of which remains unclear. This study provides a comprehensive, temporal description of the molecular events contributing to neuronal injury after transient cerebral ischemia. Intraluminal middle cerebral artery occlusion (MCAO) was performed to induce a 2-h ischemia with reperfusion. Microarray analysis was then performed on the infarct cortex of wild-type (WT) and glutathione peroxidase-1 (a maj ...[more]
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