Differential Gene Expression of Soluble CD8+ T-cell mediated suppression of HIV replication in three older children

ABSTRACT: Goal: To compare the gene expression profiles from pediatric patients with each other, with those reported in adults and in those related to exosomes. Background: Suppression of human immunodeficiency virus (HIV) replication by CD8+ T-cells (CD8 suppression) contributes to survival in adults and children < 1 year. Soluble CD8 suppression can also be seen in some older children with AIDS. The factor responsible, CD8-derived antiviral factor (CAF), acts at the level of HIV RNA transcription. Differential gene expression techniques have been used to define the gene(s) mediating this phenomenon in adults. Recently, CAF has been linked to exosomes secreted by CD8+ T-cells. Objective: To compare the gene expression profiles from pediatric patients with each other, with those reported in adults a

ORGANISM(S): Homo sapiens

SUBMITTER: Ben Katz 

PROVIDER: E-GEOD-23183 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress