DOT4/dot4 null, UBP8/ubp8 null transcript arrays
Ontology highlight
ABSTRACT:
ORGANISM(S): Saccharomyces cerevisiae
SUBMITTER: Zara Nelson
PROVIDER: E-GEOD-2329 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Ubp10/Dot4p regulates the persistence of ubiquitinated histone H2B: distinct roles in telomeric silencing and general chromatin.
Gardner Richard G RG Nelson Zara W ZW Gottschling Daniel E DE
Molecular and cellular biology 20050701 14
We previously discovered that the ubiquitin protease Ubp10/Dot4p is important for telomeric silencing through its interaction with Sir4p. However, the mechanism of Ubp10p action was unknown. We now provide evidence that Ubp10p removes ubiquitin from histone H2B; cells with UBP10 deleted have increased steady-state levels of H2B ubiquitination. As a consequence, ubp10delta cells also have increased steady-state levels of histone H3 Lys4 and Lys79 methylation. Consistent with its role in silencing ...[more]
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