Definition and characterization of the systemic T cell dysregulation in untreated indolent B cell lymphoma and very early CLL

ABSTRACT: Epidemiological data show that the immune system may control or promote emergence and growth of a neoplastic lymphomatous clone. Conversely, systemic lymphomas, especially myeloma and CLL, are associated with clinical immunodeficiency. This prospective controlled study demonstrates substantially reduced circulating T helper cells, predominantly naive CD4+ cells, in patients with non-leukemic follicular and extranodal marginal zone lymphomas, but not in monoclonal gammopathy and early CLL. These numerical changes were correlated with a preactivated phenotype, hyperreactivity in vitro, presenescence, and a Th2 shift of peripheral T helper cells. No prominent alterations were found in the regulatory T cell compartment. Gene expression profiling of in vitro-stimulated CD4+ cells revealed an in

ORGANISM(S): Homo sapiens

SUBMITTER: Petros Christopoulos 

PROVIDER: E-GEOD-23293 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress