Gene expression profiling of human atherosclerotic plaque: Laser capture microscopy of smooth muscle cells and macrophages

ABSTRACT: In order to identify potential new biomarkers of atherosclerotic plaque composition we performed a large scale analysis of gene expression patterns in human atherosclerotic lesions. Whole genome expression analysis of 101 peripheral plaques identified a robust gene signature (1514 genes) dominated by inflammatory processes, and cholesterol metabolism and storage genes. Specific pathways enriched in this signature included activation of the Toll-like receptor signaling pathway, T-cell activation, cholesterol efflux, oxidative stress response, inflammatory cytokine production, vasoconstriction and lysosomal activity. Analysis of gene expression in plaque micro-dissected material revealed that the signature is strongly up-regulated in macrophage-rich regions and down-regulated in regions w

ORGANISM(S): Homo sapiens

SUBMITTER: Oscar Puig 

PROVIDER: E-GEOD-23303 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress