The gene expression response of spontaneous canine sarcomas to thermoradiotherapy – response heterogeneity and combination therapeutics

ABSTRACT: While hyperthermia has been shown to be an effective adjuvant anti-tumor treatment to radiotherapy, we still do not completely understand effects thermoradiotherapy on tumor phenotype or how these effects vary among different tumors. Here, we performed gene expression analysis in 22 spontaneous canine sarcomas before and after the first hyperthermia treatment that was administered as an adjuvant to radiotherapy. Diffusion weighted MRI (DWI) was done prior to the treatment course and at the end of therapy. Using supervised analysis, we identified significant correlation of DWI with several genes involved in VEGF signaling, telomerase, Wnt pathways and fatty acid synthesis. When the change of gene expression caused by treatment was examined, we found that thermoradiotherapy led to the induc

ORGANISM(S): Canis lupus familiaris

SUBMITTER: Jen-Tsan Chi 

PROVIDER: E-GEOD-23380 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress