Transcription profile of zebrafish hand2 (hanS6 allele) mutant embryos at 19hpf

ABSTRACT: Heart formation requires the fusion of bilateral cardiomyocyte populations as they move toward the embryonic midline. The bHLH transcription factor Hand2 is essential for cardiac fusion; however, the effector genes that execute this function of Hand2 are unknown. Here, we provide the first evidence for a downstream component of the Hand2 pathway that mediates cardiac morphogenesis. Although hand2 is expressed in cardiomyocytes, mosaic analysis demonstrates that hand2 plays a non-autonomous role in regulating cardiomyocyte movement. Gene expression profiles reveal heightened expression of fibronectin 1 (fn1) in hand2 mutant embryos. Reciprocally, overexpression of hand2 leads to decreased Fibronectin levels. Furthermore, reduction of fn1 function enables rescue of cardiac fusion in ha

ORGANISM(S): Danio rerio

SUBMITTER: Zayra Garavito-Aguilar 

PROVIDER: E-GEOD-23381 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress