Small bowel adenocarcinoma copy number profiles are more closely related to colorectal than to gastric cancers

ABSTRACT: Purpose: Small bowel adenocarcinoma (SBA) is a rare cancer and consequently the number of clinical trials has been very limited due to the small numbers of patients. Chemotherapy regimens are currently rather arbitrarily chosen between either a colorectal (CRC) or a gastric cancer (GC) regimen. Chromosomal copy number aberrations are a hallmark of solid tumours and can be measured by array comparative genomic hybridization (aCGH). The aim of the present study is to investigate whether genome-wide copy number aberrations of SBA are more similar to CRC or GC in order to support treatment of SBA according to either regimen. Experimental Design: A total of 85 GCs, CRCs and SBAs were selected from existing in house aCGH datasets based on array quality and clinical parameters. Differences a

ORGANISM(S): Homo sapiens

SUBMITTER: Oscar Krijgsman 

PROVIDER: E-GEOD-23418 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress