Mycobacteria-Dependent Expression of microRNA-142-3p Reduces WASP Family Proteins and Controls Phagocytosis

ABSTRACT: Phagocytosis requires the activation of a plethora of mechanisms that include the activation of the actin cytoskeleton guided by the Arp2/3 complex. These are promoted by activators such as the Wiskott Aldrich Syndrome Protein (WASP) family members. In order to further understand the molecular mechanisms involved in the early events leading the phagocytosis of the pathogenic Mycobacterium tuberculosis, we set out to examine potential roles of miRNAs in phagocytosis using genome-wide expression profiling to identify miRNAs differentially regulated following mycobacterial infection. One of the miRNAs activated upon infection of mouse macrophages with the non-pathogenic Mycobacterium smegmatis, the widely conserved miR-142-3p, was predicted and confirmed to target the Neural-WASP (N-WASP). Up

ORGANISM(S): Mus musculus

SUBMITTER: Jonathon Blake 

PROVIDER: E-GEOD-23429 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress