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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of S. cerevisiae histone H4 wild type and K91A mutant strain cultures

ABSTRACT: Yeast strain containing either a histone H4 wild type or K91A allele was grown in YPD to mid-log phase and harvested. Three replicates of each allele were performed

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Mark Parthun

PROVIDER: E-GEOD-2349 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Histone H4 lysine 91 acetylation a core domain modification associated with chromatin assembly.

Ye Jianxin J Ai Xi X Eugeni Ericka E EE Zhang Liwen L Carpenter Laura Rocco LR Jelinek Mary A MA Freitas Michael A MA Parthun Mark R MR

Molecular cell 20050401 1

The acetylation of the NH2-terminal tail of histone H4 by type B histone acetyltransferases (HATs) is involved in the process of chromatin assembly. Histone H4 associated with a nuclear type B HAT complex contains modifications in its globular core domain as well. In particular, acetylation was found at lysine 91. A mutation that alters this residue, which lies in the interface between histone H3/H4 tetramers and H2A/H2B dimers, confers phenotypes consistent with defects in chromatin assembly su ...[more]

PMID: 15808514

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