Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Copy number aberrations of genes regulating normal thymus development in thymic epithelial tumors

ABSTRACT: Thymic epithelial tumors are a group of neoplasms with heterogeneous histological features and clinical behavior. The identification of markers useful to predict patient prognosis and molecular targets for therapies is limited by a very little understanding of the biology of these neoplasms. We evaluated the copy number (CN) aberrations of genes involved in normal thymus development in thymic epithelial tumors, following the intriguing idea that the ectopic deregulation of genes relevant for proliferation and differentiation of embryonic cells, can contribute to tumor growth. Frequent CN losses of FOXC1 were observed in more aggressive tumors and correlated with a reduced protein expression; tumors negative for FOXC1 expression were associated with a shorter time to progression. In addition, FOXC1 showed tumor suppressor activity in in-vitro models. Our data indicate that FOXC1 loss can identify a group of thymic epithelial tumors with poor prognosis, possibly because its tumor suppressor properties. Two color array CGH of a series of 59 thymic epithelial tumors plus evaluation of 2 thymic carcinoma cell lines and one thymoma B1 cell line.

ORGANISM(S): Homo sapiens

SUBMITTER: Iacopo Petrini

PROVIDER: E-GEOD-23540 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Copy number aberrations of genes regulating normal thymus development in thymic epithelial tumors.

Petrini Iacopo I Wang Yisong Y Zucali Paolo A PA Lee Hye Seung HS Pham Trung T Voeller Donna D Meltzer Paul S PS Giaccone Giuseppe G

Clinical cancer research : an official journal of the American Association for Cancer Research 20130226 8

<h4>Purposes</h4>To determine whether the deregulation of genes relevant for normal thymus development can contribute to the biology of thymic epithelial tumors (TET).<h4>Experimental design</h4>Using array comparative genomic hybridization, we evaluated the copy number aberrations of genes regulating thymus development. The expression of genes most commonly involved in copy number aberrations was evaluated by immunohistochemistry and correlated with patients' outcome. Correlation between FOXC1 ...[more]

PMID: 23444221

Publication: 1/2

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Copy number aberrations of genes regulating normal thymus development in thymic epithelial tumors

Publications

Copy number aberrations of genes regulating normal thymus development in thymic epithelial tumors.

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