Competition and cooperativity determine transcription factor binding and regulation

ABSTRACT: Binding of transcription factors to DNA is a key regulatory step in the control of gene expression. DNA sequences with high affinity for transcription factors occur more frequently in the genome than instances of genes bound or regulated by these factors. How specific gene regulation is achieved by transcription factors remains unclear. We used genome-wide approaches to study how trans factors shape the binding and regulatory landscape of Pho4, a budding yeast transcription factor that activates gene expression in response to phosphate limitation. In no phosphate (0mM phosphate) medium, Pho4 is transported into the nucleus and activates transcription of a set of genes (PHO) that are necessary for cell survival in phosphate limited environment. In high phosphate (10mM phosphate) medium,

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Xu Zhou 

PROVIDER: E-GEOD-23580 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress