Expression data from colonic biopsy samples of infliximab treated ulcerative colitis patients

ABSTRACT: A gene expression profiling sub-study was conducted in which colonic biopsy samples were collected for RNA extraction and hybridization to microarrays from 48 patients with UC who were participating in ACT 1, a placebo-controlled study of infliximab. Gene expression profiles from infliximab responders were compared with those of baseline and infliximab non-responder samples. Infliximab had a significant effect on mRNA expression in treatment responders, with both infliximab dose and duration of treatment having an effect. Genes affected are primarily involved with inflammatory response, cell-mediated immune responses, and cell-to-cell signaling. Infliximab non-responders had a molecular phenotype that closely resembled that of untreated patients with UC. Unlike responders, non-responders

ORGANISM(S): Homo sapiens

SUBMITTER: K Li 

PROVIDER: E-GEOD-23597 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress